A new study by a joint group of Chinese and American scientists has shown risk groups for Covid-19, and has also suggested which signs could serve as precursors to an unfavorable prognosis based on the systematization of deaths.
It is reported by Naked Science.
The authors identified the most common features in 85 Covid-19 patients who died in the initial epicenter of the epidemic – Wuhan, China. All of the deaths occurred in the early stages of the spread of the disease. The article was published in the American Thoracic Society. American Journal of Respiratory and Critical Care Medicine.
As part of this retrospective observational study, a comparative analysis of electronic medical records of patients with Covid-19 was performed. All were hospitalized for coronavirus symptoms in two Wuhan medical facilities – Hanan Hospital and Wuhan Hospital from January 9 to February 15. The diagnosis of each was confirmed by laboratory methods, all these patients died from the coronavirus, despite the efforts of the doctors.
The team reviewed the medical records available on these individuals, their medical history, data on the course of their coronavirus infection, symptoms, laboratory data, CT results and clinical picture, as well as all the ailments and associated chronic diseases they had before and on the onset of the disease. Then, a statistical analysis was performed.
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“The greatest number of deaths in our cohort involved men over 50 with chronic non-infectious diseases,” summarize the authors of the results of the map analysis. The average age of death was 65.8 years and the majority (72.9% of all deaths) were men. Hypertension, diabetes and coronary heart disease were the most common concomitant chronic diseases.
Scientists hope their work will help to more reasonably show the danger of Covid-19 for at-risk groups.
The most common symptoms for patients who later died were fever, shortness of breath (shortness of breath) and weakness. In addition, just over 80% of patients at this time had very low levels of eosinophils in the blood. Complications included respiratory failure, shock, acute respiratory distress syndrome (ARDS) and cardiac arrhythmia.
Most patients received antibiotics, antivirals and glucocorticosteroids. Immunoglobulin or interferon alfa-2b has been given intravenously to some. The researchers noted that the effectiveness of antiviral agents and immunosuppressive drugs in combating the causative agent of Covid-19 has not yet been fully studied. The authors note that the combinations of these substances did not help the dead. Most of the patients examined died from multiple organ failure.
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The authors call the discovery of one of the most important conclusions of their work that although the respiratory symptoms do not develop immediately and for up to a week, the patient with an already confirmed diagnosis may not have one from the start , the patient’s condition can deteriorate quickly and quickly.
The time interval between patient admission and death in the cases studied by the scientists was on average 6.35 days. A good “external” marker of this infection, according to scientists, is the rapid onset of shortness of breath.
Based on the data collected, the researchers indicate that eosinophilopenia – an abnormally low level of eosinophils in the blood – may serve as an indicator of a poor prognosis. They also noted that the onset of shortness of breath could be used as an observation symptom of Covid-19. In addition, they noted that a combination of antimicrobials (antivirals, antibiotics) did not help these patients very much.
The authors emphasize that detailed documentation of symptoms and analysis of patient data from different pandemic focal points with different disease onset dates is important in order to understand how the virus and the manifestations of infection caused. by it change.
Photo: France 24
According to the materials: ukrinform.ru